The presence of proteinase inhibitors represents an important factor in the biological regulation of enzymes and enzyme systems. Their role is of particular importance in proteinase systems that are regulated or limited by their interference.
Proteinase inhibitors are found in great distribution in vertebrates, invertebrates as well as plants. Many inhibitors show similar properties and features and have been the subjects of biochemical research for a long time.
The polyvalent proteinase inhibitor Aprotinin was discovered in the bovine pancreas by Kunitz and Northrop in 1936. It has also been found in other bovine organs, particularly the lungs. After its subsequent isolation, its peptide character, its molecular weight (MW), and its effect on the enzymes trypsin and chymotrypsin were determined and fully described. Subsequent investigations over the ensuing decades described its effects as an inhibitor of the coagulation and fibrinolytic systems. Its amino acid sequence and the tertiary structure have also been elucidated.
Today, modern methods of separation through protein chemistry allow for extremely high purification and large scale production of Aprotinin
Manufacturers of Aprotinin:
- Fermentation Biotec GmbH
- eagle-pharmaceutical d.o.o.
More Informationen about Aprotinin:
Wikipedia Aprotinin (en)
Wikipedia Aprotinin (de)